Blar i forfatter "Pettersen, Ann Kristin"

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    • Liposomal formulations for membrane active antimicrobials – Assuring safety through an optimised drug delivery system 

      Pettersen, Ann Kristin (Master thesis; Mastergradsoppgave, 2020-05-13)
      Skin and soft tissue infections (SSTIs) and chronic wounds are major challenges for the healthcare system worldwide. The additional rapid development of antibacterial resistance and lack of successful treatment strategies increase the chance for infected chronic wounds to be fatal for the patient. Therefore, there is a need for more efficient dermal antimicrobial therapies. A class of promising ...

    • Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Pettersen, Ann Kristin; Vitali, Beatrice; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-16)
      Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...